effect of intravenous glutamine on the protein expression changes, caspase-12 and apoptosis in renal tubulus russ male, rattusnovergicusstrain wistar, exposed by cisplastin

Cisplatin efficacy is dependent on dose. The cisplatin-induced apoptosis pathway can go through the ER stress which will activate Bax and Bak (proapoptosis) causing calcium homeostasis disorders to occur. Glutamine protective effect caspase-12 expression prevention of apoptotic events in renal proximal tubular epithelial cells unknown. This further study analyzes effects intravenous glutamine caspase- 12 male white rats exposed cisplatin. control group (P0) consisted 10 individuals, P1 day 7 was given a single dose 20mg / kg intraperitoneal cisplatin injection, P2 1-7 injection 100mg also kg. number expressing observed after 72 hours. Caspase-12 data were collected for processing analysis. There significant (p <0.0001) giving cell apoptosis. inhibit caspase-12, incidence by